Basic eye test could diagnose diabetes and hypertension

Scientists see the light with diabetes and hypertension breakthrough

 

Devrim niteliğinde buluş: Polarize ışıkla anında diyabet ve hipertansiyon tespiti

تشخیص دیابت و فشار خون بالا با نور پلاریزه

 

Below, you find hyperlinks to papers that have been published on various polarization-sensitive optical coherence tomography (PS-OCT) topics. PS-OCT systems for retinal imaging can be custom designed and built. In practice, I build these as a consultant. For a standard system, a complete build takes about two weeks to a month. For a custom system equipped with adaptive optics, the time to build roughly doubles. I have built all my systems for human retinal imaging, but can change the optics for small animal imaging.

Our Stokes-vector based PS-OCT systems are easy to use. They can quantify the cumulative phase retardation induced by birefringent tissue. They can also measure the relative fast axis orientation of tissue and the birefringence of tissue. They excel at measuring tissue that is easy to segment, such as the nerve fiber layer and the RPE-Bruch's membrane complex. We also managed to analyze the birefringence of retinal blood vessel walls.

Each bullet point is a hyperlink.

• Our systems are based on Stokes-vector based PS-OCT
• They are made with a single-camera polarization-sensitive spectrometer (2007)
• They can be equipped with 6.0 mm aperture adaptive optics for a 3 micrometer lateral resolution (2009)
• They can be equipped with 2.8 mm aperture adaptive optics for a ~7 micrometer lateral resolution and a 10 degree field of view (2019)
• The axial resolution can be increased to 3 micrometer by using light sources with a broader bandwidth (2004)
• Here are results made with an ultra-high resolution PS-OCT system (2022)
• We used PS-OCT to quantify the polarization properties of the human retinal nerve fiber layer, in vivo (2004)
• We used PS-OCT to quantify the polarization properties of the Henle fiber layer, in vivo (2009)
• We used PS-OCT to quantify the polarization properties of the retinal pigmented epithelium, in vivo (2018)
• We used PS-OCT to quantify the polarization properties of human retinal vessel walls, in vivo (2021)
• PS-OCT can be used to measure the difference in thickness and birefringence in hypertensive vessel walls (2023)
• PS-OCT can be used to measure the polarization properties of diabetic vessel walls (2023)
• Newspaper article on diagnosing diabetes with our technology